Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | MPC2 | O95563 | 2/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000434 | 0.88 | PPARG (0.57) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL8000917 | 0.85 | PPARG (0.53) | PPARGCYP3A4RXRAFFAR1PPARA | |
| Ploglitazone SCHEMBL12160093 | 0.82 | PPARG (0.75) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL6931816 | 0.82 | FFAR1 (0.66) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL7987768 | 0.82 | PPARG (0.57) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL12515224 | 0.81 | FFAR1 (0.69) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL12628242 | 0.81 | PPARG (0.63) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL6381220 | 0.79 | FFAR1 (0.65) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL7996885 | 0.79 | PPARG (0.61) | PPARGCYP3A4RXRAFFAR1PPARA | |
| SCHEMBL7998440 | 0.79 | PPARG (0.61) | PPARGCYP3A4RXRAFFAR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288096-B1 | ANTIDIABETIC AGENTS, HYPOTENSIVE AGENTS, AND ANTICHOLESTEROL AGENTS | ASTRAZENECA AB (SE) | 2001-09-11 | — | — | US | disclosed |