Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 7/20 | 0.60 |
| ▸ | FNTB | P49356 | 7/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7996917 | 1.00 | FNTA (0.60) | FNTAFNTBCYP1A2CYP3A4CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL8869811 | 0.89 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| Trifluoroacetic Acid SCHEMBL8869802 | 0.89 | FNTA (0.49) | FNTAFNTBPGGT1B | |
| SCHEMBL7994646 | 0.78 | FNTA (0.60) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7998320 | 0.77 | FNTA (0.59) | FNTAFNTBPGGT1B | |
| SCHEMBL8934697 | 0.75 | FNTA (0.56) | FNTAFNTBMAPTPGGT1B | |
| SCHEMBL8107197 | 0.75 | FNTA (1.00) | FNTAFNTBPGGT1B | |
| SCHEMBL7996775 | 0.72 | FNTA (0.66) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL8869016 | 0.71 | FNTA (0.64) | FNTAFNTBPGGT1B | |
| SCHEMBL21847980 | 0.70 | PTGS1 (0.69) | CYP1A2MAPTALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |