Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694718 | 1.00 | CYP1A2 (0.33) | CYP1A2CYP2D6HIF1ATSHR | |
| SCHEMBL2745122 | 1.00 | CYP1A2 (0.33) | CYP1A2CYP2D6HIF1ATSHR | |
| SCHEMBL2744914 | 1.00 | CYP1A2 (0.33) | CYP1A2CYP2D6HIF1ATSHR | |
| SCHEMBL28045902 | 0.84 | TSHR (0.39) | CYP1A2CYP2D6HIF1ATSHR | |
| SCHEMBL14475696 | 0.80 | ADRB3 (0.34) | CYP1A2CYP2D6HIF1ATSHR | |
| SCHEMBL9721750 | 0.80 | KDM4E (0.46) | — | |
| SCHEMBL17158431 | 0.80 | AOC3 (0.43) | TSHR | |
| SCHEMBL14384675 | 0.79 | CYP1A2 (0.50) | CYP1A2CYP2D6HIF1A | |
| SCHEMBL8260418 | 0.79 | CYP1A2 (0.50) | CYP1A2CYP2D6HIF1A | |
| SCHEMBL8256890 | 0.79 | CYP1A2 (0.50) | CYP1A2CYP2D6HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9273134-B2 | Inhibitors of receptor tyrosine kinases and methods of use thereof | YALE UNIVERSITY (US) | 2016-03-01 | — | — | US | disclosed |
| US-9273134-B2 | Inhibitors of receptor tyrosine kinases and methods of use thereof | YALE UNIVERSITY (US) | 2016-03-01 | — | — | US | disclosed |
| US-8410028-B2 | Methods for synthesis of encoded libraries | GLAXOSMITHKLINE LLC (US) | 2013-04-02 | — | — | US | disclosed |
| US-8410028-B2 | Methods for synthesis of encoded libraries | GLAXOSMITHKLINE LLC (US) | 2013-04-02 | — | — | US | disclosed |
| US-20120328599-A1 | INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF | YALE UNIVERSITY (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120328599-A1 | INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF | YALE UNIVERSITY (US) | 2012-12-27 | — | — | US | disclosed |
| US-20120071329-A1 | METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071329-A1 | METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | US | disclosed |
| US-20110311538-A1 | INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF | YALE UNIVERSITY (US) | 2011-12-22 | — | — | US | disclosed |
| US-20110311538-A1 | INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF | YALE UNIVERSITY (US) | 2011-12-22 | — | — | US | disclosed |
| US-7989395-B2 | Methods for identifying compounds of interest using encoded libraries | GLAXOSMITHKLINE LLC (US) | 2011-08-02 | — | — | US | disclosed |
| US-7989395-B2 | Methods for identifying compounds of interest using encoded libraries | GLAXOSMITHKLINE LLC (US) | 2011-08-02 | — | — | US | disclosed |
| US-7972994-B2 | Methods for synthesis of encoded libraries | GLAXOSMITHKLINE LLC (US) | 2011-07-05 | — | — | US | disclosed |
| US-7972994-B2 | Methods for synthesis of encoded libraries | GLAXOSMITHKLINE LLC (US) | 2011-07-05 | — | — | US | disclosed |
| EP-1910538-B1 | METHODS FOR SYNTHESIS OF ENCODED LIBRARIES | PRAECIS PHARM INC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20070224607-A1 | Methods for identifying compounds of interest using encoded libraries | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2007-09-27 | — | — | US | disclosed |
| US-20070224607-A1 | Methods for identifying compounds of interest using encoded libraries | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2007-09-27 | — | — | US | disclosed |
| US-7244853-B2 | Dioxanes and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-07-17 | — | — | US | disclosed |
| US-20070042401-A1 | Methods for synthesis of encoded libraries | PRAECIS PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070042401-A1 | Methods for synthesis of encoded libraries | PRAECIS PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110311538-A1 | INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF | ABL1, PDGFRA, PDGFRB | CYP1A2 4578/4885CYP2D6 3193/4885HIF1A 4162/4885 |
| US-20120328599-A1 | INHIBITORS OF RECEPTOR TYROSINE KINASES (RTK) AND METHODS OF USE THEREOF | ERBB2, ERBB3, ERBB4 | CYP1A2 4793/4885CYP2D6 4637/4885HIF1A 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.