Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689808 | 0.81 | CYP3A4 (0.64) | GNRHR | |
| SCHEMBL7995810 | 0.81 | GNRHR (0.54) | GNRHR | |
| SCHEMBL27686168 | 0.81 | HTR2A (0.58) | — | |
| Trimethylammonium SCHEMBL8695107 | 0.80 | HTR2A (0.51) | GNRHR | |
| SCHEMBL8692594 | 0.80 | GNRHR (0.56) | GNRHR | |
| Iodide SCHEMBL8695111 | 0.80 | GNRHR (0.47) | GNRHR | |
| SCHEMBL4423600 | 0.75 | MAPT (0.65) | — | |
| SCHEMBL8694550 | 0.75 | TLR8 (0.53) | — | |
| SCHEMBL30047453 | 0.74 | NR1I3 (0.51) | — | |
| SCHEMBL28906384 | 0.74 | NR1I3 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0868178-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2000-03-29 | — | — | EP | claimed |
| EP-0868178-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-10-07 | — | — | EP | claimed |
| US-5756507-A | TREATING SEX HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | claimed |
| WO-1997021435-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | claimed |
| US-5756507-A | TREATING SEX HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |