Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL982569 | 0.88 | TSHR (0.52) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL983265 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL983333 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL983633 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL984155 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL983520 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL984167 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL982098 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL981726 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 | |
| SCHEMBL973268 | 0.86 | TSHR (0.50) | TSHRGABRA1GABRB2CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284918-B1 | ENZYME INHIBITORS | VANDERBILT UNIVERSITY | 2001-09-04 | — | — | US | disclosed |