SCHEMBL7998538

SCHEMBL7998538

O=C(CCc1cccc(OCc2ccccc2)c1)CCc1cccc(OCc2ccccc2)c1

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 5/20 0.69
CYP4F2 P78329 1/20 0.69
CYP4A11 Q02928 1/20 0.69
NR4A2 P43354 1/20 0.62
MAOB P27338 3/20 0.59
FFAR4 Q5NUL3 2/20 0.58
CYP2D6 P10635 1/20 0.56
TSHR P16473 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
SMPD1 P17405 1/20 0.56
LTB4R Q15722 1/20 0.56
LTB4R2 Q9NPC1 1/20 0.56
BCHE P06276 1/20 0.55
KDM4E B2RXH2 1/20 0.55
ALDH1A1 P00352 1/20 0.55
PKM P14618 1/20 0.55
SRD5A2 P31213 1/20 0.55
MGLL Q99685 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2772855 0.90 FFAR1 (0.83) FFAR1CYP4F2CYP4A11NR4A2FFAR4
SCHEMBL12618315 0.88 FFAR1 (0.66) FFAR1CYP4F2CYP4A11NR4A2MAOB
SCHEMBL2912575 0.88 FFAR1 (0.66) FFAR1CYP4F2CYP4A11NR4A2MAOB
SCHEMBL3660617 0.88 FFAR1 (0.66) FFAR1CYP4F2CYP4A11NR4A2MAOB
SCHEMBL2908859 0.86 FFAR1 (0.64) FFAR1CYP4F2CYP4A11NR4A2MAOB
SCHEMBL10683288 0.85 FFAR1 (0.63) FFAR1CYP4F2CYP4A11NR4A2MAOB
SCHEMBL5763262 0.84 FFAR1 (0.70) FFAR1CYP4F2CYP4A11NR4A2MAOB
SCHEMBL23771271 0.84 CYP2D6 (0.71) FFAR1CYP4F2CYP4A11NR4A2MAOB
SCHEMBL7332614 0.83 FFAR1 (0.62) FFAR1FFAR4
SCHEMBL10733098 0.83 FFAR1 (0.60) FFAR1CYP4F2CYP4A11NR4A2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6046355-A TOLUENE-4-THIOSULFONIC ACID S-ESTERS AS CHEMICAL INTERMEDIATES FOR VIRICIDES AND ASPARTYL PROTEASE INHIBITORS; AIDS WARNER-LAMBERT COMPANY (US) 2000-04-04 US disclosed
EP-0935597-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1999-08-18 EP disclosed
US-5834506-A TREATMENT OF HIV, AIDS; ANTIVIRAL ACTIVITY IMPROVED BY JUDICIOUS PLACEMENT OF POLAR SUBSTITUENTS WARNER-LAMBERT COMPANY (US) 1998-11-10 US disclosed
WO-1998019997-A2 DIHYDROPYRONES WITH IMPROVED ANTIVIRAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1998-05-14 WO disclosed