Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.86 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.70 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.70 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.70 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.70 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.70 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.70 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.70 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.70 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12577241 | 0.89 | DRD4 (0.84) | DRD4GAATSHRPOLBDRD2 | |
| SCHEMBL8007258 | 0.88 | DRD4 (0.81) | DRD4GRIN2DGRIN3BADRA1DADRA1A | |
| SCHEMBL12577227 | 0.83 | TSHR (0.74) | DRD4GAATSHRPOLBABCB1 | |
| SCHEMBL8007642 | 0.83 | DRD4 (0.72) | DRD4GAATSHRPOLBDRD2 | |
| SCHEMBL13229781 | 0.81 | DRD4 (0.74) | DRD4GRIN2DGRIN3BADRA1DADRA1A | |
| SCHEMBL7402131 | 0.80 | TMEM97 (0.82) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL7402650 | 0.79 | TMEM97 (0.80) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL12120898 | 0.79 | MEN1 (0.84) | GRIN2DGRIN3BADRA1DADRA1AADRA1B | |
| SCHEMBL14864563 | 0.78 | DRD4 (0.80) | DRD4GAAPOLBHSD17B10KMT2A | |
| SCHEMBL12576638 | 0.78 | DRD4 (0.80) | DRD4GAATSHRHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160223-A1 | NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders | EMORY UNIVERSITY | 2011-06-30 | — | — | US | disclosed |
| US-20110160223-A1 | NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders | EMORY UNIVERSITY | 2011-06-30 | — | — | US | disclosed |
| WO-2009137843-A2 | NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | EMORY UNIVERSITY (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160223-A1 | NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders | GRIN2A, GRIN2B, GRIN1 | DRD4 264/4885GRIN2D 5/4885GRIN3B 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.