Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 15/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 14/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 14/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992761 | 0.98 | OPRL1 (0.57) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL7999578 | 0.97 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL7992767 | 0.94 | OPRL1 (0.58) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL7996361 | 0.91 | OPRL1 (0.57) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL7995750 | 0.89 | OPRL1 (0.60) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL7996228 | 0.87 | OPRL1 (0.64) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL5102059 | 0.86 | OPRL1 (0.65) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL5102055 | 0.86 | OPRL1 (0.65) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL5098400 | 0.86 | OPRL1 (0.65) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL5108236 | 0.82 | OPRL1 (0.66) | OPRL1OPRM1OPRD1OPRK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001036418-A1 | NOVEL TRIAZASPIRODECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | NOVO NORDISK A/S (DK) | 2001-05-25 | — | — | WO | claimed |
| WO-2001036418-A1 | NOVEL TRIAZASPIRODECANONES WITH HIGH AFFINITY FOR OPIOID RECEPTOR SUBTYPES | NOVO NORDISK A/S (DK) | 2001-05-25 | — | — | WO | disclosed |