Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 8/20 | 0.45 |
| ▸ | FNTB | P49356 | 8/20 | 0.45 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8000410 | 1.00 | NPC1 (0.45) | NPC1LMNATP53TSHRHTT | |
| Hydrochloric Acid SCHEMBL8870302 | 0.99 | NPC1 (0.44) | NPC1LMNATP53TSHRHTT | |
| Hydrochloric Acid SCHEMBL8870297 | 0.99 | NPC1 (0.44) | NPC1LMNATP53TSHRHTT | |
| SCHEMBL7993175 | 0.86 | FNTA (0.48) | NPC1LMNATP53HTTRAB9A | |
| SCHEMBL7993171 | 0.86 | FNTA (0.48) | NPC1LMNATP53HTTRAB9A | |
| SCHEMBL7995119 | 0.86 | FNTA (0.48) | NPC1LMNATP53HTTRAB9A | |
| Hydrochloric Acid SCHEMBL8869226 | 0.85 | FNTA (0.47) | NPC1LMNATP53HTTRAB9A | |
| Hydrochloric Acid SCHEMBL7982918 | 0.85 | FNTA (0.47) | NPC1LMNATP53HTTRAB9A | |
| Hydrochloric Acid SCHEMBL7982923 | 0.85 | FNTA (0.47) | NPC1LMNATP53HTTRAB9A | |
| SCHEMBL7993272 | 0.81 | MAPT (0.48) | NPC1LMNATP53HTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | claimed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | claimed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | claimed |
| EP-0817629-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2000-03-08 | — | — | EP | disclosed |
| EP-0817629-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5631280-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1996030014-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |