Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 5/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | SELP | P16109 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8003931 | 1.00 | HMGCR (0.37) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL8000450 | 1.00 | HMGCR (0.37) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL7998354 | 1.00 | HMGCR (0.37) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL7996959 | 1.00 | HMGCR (0.37) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL3032190 | 0.90 | HMGCR (0.36) | HMGCRPTPN7RECQLTDP1TSHR | |
| SCHEMBL8000474 | 0.86 | HMGCR (0.38) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL8003889 | 0.86 | HMGCR (0.38) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL7998473 | 0.86 | HMGCR (0.38) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL8000604 | 0.86 | HMGCR (0.38) | HMGCRPTPN7RECQLTDP1SELP | |
| SCHEMBL8000467 | 0.86 | HMGCR (0.38) | HMGCRPTPN7RECQLTDP1SELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288038-B1 | ACCELERATE APOLIPOPROTEIN E PRODUCTION; NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE; ANTILIPEMIC AGENTS | NISSHIN SEIFUN GROUP INC. (JP) | 2001-09-11 | — | — | US | disclosed |
| EP-1028126-A1 | DEPSIPEPTIDE DERIVATIVES BEARING PIPERAZINONE RINGS | Nisshin Flour Milling Co., Ltd. (JP) | 2000-08-16 | — | — | EP | disclosed |