Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.54 |
| ▸ | CNR2 | P34972 | 6/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5537808 | 0.94 | NR1H2 (0.60) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| SCHEMBL16329012 | 0.89 | TSHR (0.61) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| SCHEMBL7762911 | 0.89 | TSHR (0.61) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL2247210 | 0.87 | TSHR (0.59) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| Hydrochloric Acid SCHEMBL15826292 | 0.87 | TSHR (0.59) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| SCHEMBL8092493 | 0.87 | TSHR (0.63) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| SCHEMBL14288514 | 0.86 | NR1H2 (0.56) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| SCHEMBL10620289 | 0.85 | NR1H2 (0.58) | NR1H2NR1H3CNR2TSHRCYP2C19 | |
| SCHEMBL8019595 | 0.84 | CNR2 (0.41) | CNR2 | |
| SCHEMBL28128909 | 0.84 | CNR2 (0.41) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1060173-C | Heterocyclic compound with activity against diabetes and preparation and application of same | MITSUTAKA CO LTD (JP) | 2001-01-03 | — | — | CN | disclosed |
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5962470-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 1999-10-05 | — | — | US | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5834501-A | TREATING DIABETES OR HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5739345-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1998-04-14 | — | — | US | disclosed |
| CN-1157288-A | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1997-08-20 | — | — | CN | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |
| CN-1118781-A | Heterocyclic compound with activity against diabetes and preparation and application of same | MITSUTAKA CO LTD (JP) | 1996-03-20 | — | — | CN | disclosed |
| EP-0676398-A2 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1995-10-11 | — | — | EP | disclosed |