Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 2/20 | 0.64 |
| ▸ | DHFR | P00374 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.55 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.55 |
| ▸ | GMNN | O75496 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | THPO | P40225 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8001370 | 1.00 | ERBB2 (0.64) | ERBB2DHFRNPC1CSNK1DALDH1A1 | |
| SCHEMBL6396491 | 0.95 | ERBB2 (0.69) | ERBB2DHFRNPC1CSNK1DALDH1A1 | |
| SCHEMBL6408143 | 0.95 | ERBB2 (0.69) | ERBB2DHFRNPC1CSNK1DALDH1A1 | |
| SCHEMBL8002167 | 0.89 | ERBB2 (0.64) | ERBB2MDM2FLT3EGFR | |
| SCHEMBL8002301 | 0.89 | CCNE1 (0.54) | ERBB2DHFRCCNE1CDK2MDM2 | |
| SCHEMBL8002300 | 0.89 | CCNE1 (0.54) | ERBB2DHFRCCNE1CDK2MDM2 | |
| SCHEMBL8002163 | 0.89 | ERBB2 (0.64) | ERBB2MDM2FLT3EGFR | |
| SCHEMBL6404623 | 0.83 | ERBB2 (0.69) | ERBB2MDM2FLT3EGFR | |
| SCHEMBL6404622 | 0.83 | ERBB2 (0.69) | ERBB2MDM2FLT3EGFR | |
| SCHEMBL6390048 | 0.83 | CCNE1 (0.58) | ERBB2DHFRCCNE1CDK2MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |
| WO-2000008202-A2 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN, INC. (US) | 2000-02-17 | — | — | WO | disclosed |