Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008466 | 0.92 | MAPT (0.59) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1009834 | 0.85 | MAPT (0.65) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL8004881 | 0.80 | MAPT (0.78) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1007724 | 0.80 | MAPT (0.77) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1008552 | 0.77 | MAPT (0.80) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1008510 | 0.77 | MAPT (0.64) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1895472 | 0.75 | MAPT (0.75) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1008056 | 0.75 | MAPT (1.00) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1010068 | 0.74 | MAPT (0.65) | MAPTTP53LMNASMN1; SMN2MEN1 | |
| SCHEMBL1893298 | 0.74 | MAPT (0.67) | MAPTTP53LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119088-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |