Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13750907 | 0.95 | PDE4B (0.48) | PDE4BMAPK1RPS6KA1PDE5ANR3C1 | |
| SCHEMBL3426160 | 0.95 | PDE4B (0.49) | PDE4BMAPK1PDE5ANR3C1 | |
| SCHEMBL3422318 | 0.95 | PDE4B (0.49) | PDE4BMAPK1RPS6KA1PDE5ANR3C1 | |
| SCHEMBL3428603 | 0.92 | PDE4B (0.50) | PDE4B | |
| SCHEMBL8011932 | 0.92 | PDE4B (0.50) | PDE4BMAPK1RPS6KA1PDE5A | |
| SCHEMBL1364608 | 0.92 | PDE4B (0.51) | PDE4BMAPK1RPS6KA1PDE5ANR3C1 | |
| SCHEMBL3430830 | 0.92 | PDE4B (0.51) | PDE4BMAPK1RPS6KA1PDE5ANR3C1 | |
| SCHEMBL7999785 | 0.91 | PDE4B (0.49) | PDE4BMAPK1RPS6KA1 | |
| SCHEMBL1362184 | 0.91 | PDE4B (0.49) | PDE4BMAPK1RPS6KA1PDE5ANR3C1 | |
| SCHEMBL3428746 | 0.90 | PDE4B (0.48) | PDE4BPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |