Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 12/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 12/20 | 0.56 |
| ▸ | KDR | P35968 | 12/20 | 0.56 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.41 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405087 | 0.87 | AURKA (0.54) | PDGFRBFGFR1KDRZAP70EGFR | |
| SCHEMBL6405084 | 0.87 | AURKA (0.54) | PDGFRBFGFR1KDRZAP70EGFR | |
| SCHEMBL6390811 | 0.83 | FGFR1 (0.78) | PDGFRBFGFR1KDRZAP70SRC | |
| SCHEMBL6390808 | 0.83 | FGFR1 (0.78) | PDGFRBFGFR1KDRZAP70SRC | |
| SCHEMBL6405823 | 0.78 | ZAP70 (0.67) | PDGFRBFGFR1KDRZAP70SRC | |
| SCHEMBL6405826 | 0.78 | ZAP70 (0.67) | PDGFRBFGFR1KDRZAP70SRC | |
| SCHEMBL6389254 | 0.78 | AURKA (0.64) | PDGFRBFGFR1KDRZAP70SRC | |
| SCHEMBL6406975 | 0.78 | FGFR1 (0.69) | PDGFRBFGFR1KDRZAP70SRC | |
| SCHEMBL6406978 | 0.78 | FGFR1 (0.69) | PDGFRBFGFR1KDRZAP70SRC | |
| SCHEMBL6405439 | 0.78 | AURKA (0.64) | PDGFRBFGFR1KDRZAP70SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008202-A9 | 3-METHYLIDENYL-2-INDOLINONE MODULATORS OF PROTEIN KINASE | SUGEN INC (US) | 2000-07-27 | — | — | WO | disclosed |