Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 16/20 | 0.53 |
| ▸ | MTOR | P42345 | 10/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.44 |
| ▸ | ATR | Q13535 | 3/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008147 | 1.00 | PIK3CA (0.53) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4450942 | 1.00 | PIK3CA (0.53) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8010127 | 0.92 | PIK3CA (0.53) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8012812 | 0.89 | PIK3CA (0.55) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4023502 | 0.87 | PIK3CA (0.56) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4455822 | 0.87 | PIK3CA (0.56) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4456085 | 0.85 | PIK3CA (0.53) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8003400 | 0.85 | PIK3CA (0.53) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8003310 | 0.83 | PIK3CA (0.62) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4447612 | 0.82 | PIK3CA (0.67) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093981-A1 | TRIAZINE COMPOUNDS AS KINASE INHIBITORS | S BIO PTE LTD (SG) | 2009-07-30 | — | — | WO | disclosed |