Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.51 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.51 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029247 | 0.86 | MAPT (0.70) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL17124160 | 0.84 | MAPT (0.59) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL12637181 | 0.81 | KMT2A (0.64) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL8003410 | 0.78 | CFTR (0.70) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL1672374 | 0.77 | KMT2A (0.56) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL1672377 | 0.77 | KMT2A (0.56) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL16606094 | 0.77 | KMT2A (0.70) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL8289618 | 0.77 | MAPT (0.59) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL8290519 | 0.76 | MAPT (0.71) | MAPTKMT2AMEN1KDM4ELMNA | |
| SCHEMBL12671818 | 0.75 | CFTR (0.70) | MAPTKMT2AMEN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120803-A2 | WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-01 | — | — | WO | disclosed |