Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 7/20 | 0.79 |
| ▸ | DUSP22 | Q9NRW4 | 5/20 | 0.61 |
| ▸ | BCL2 | P10415 | 5/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.57 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.54 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882107 | 0.88 | CFTR (1.00) | CFTRDUSP22BCL2MCL1BCL2L1 | |
| SCHEMBL1882106 | 0.88 | CFTR (1.00) | CFTRDUSP22BCL2MCL1BCL2L1 | |
| SCHEMBL1882111 | 0.88 | CFTR (1.00) | CFTRDUSP22BCL2MCL1BCL2L1 | |
| SCHEMBL1887625 | 0.84 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 | |
| SCHEMBL1110973 | 0.84 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 | |
| SCHEMBL1110972 | 0.84 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 | |
| SCHEMBL12637158 | 0.80 | CFTR (0.84) | CFTRDUSP22BCL2MCL1BCL2L1 | |
| SCHEMBL1877096 | 0.78 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 | |
| SCHEMBL1877097 | 0.78 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 | |
| SCHEMBL1877094 | 0.78 | CFTR (1.00) | CFTRDUSP22MEN1KMT2ANLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120803-A2 | WATER SOLUBLE SMALL MOLECULE INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-01 | — | — | WO | disclosed |