Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8227066 | 1.00 | BACE1 (0.34) | BACE1CNR2GSK3BKCNH2BACE2 | |
| SCHEMBL8224975 | 0.95 | CNR2 (0.34) | BACE1CNR2GSK3BKCNH2 | |
| SCHEMBL8002693 | 0.95 | CNR2 (0.34) | BACE1CNR2GSK3BKCNH2 | |
| SCHEMBL13601242 | 0.95 | CNR2 (0.34) | BACE1CNR2GSK3BKCNH2 | |
| SCHEMBL13601238 | 0.90 | CNR2 (0.36) | CNR2GSK3BKCNH2CYP1A2CYP2D6 | |
| SCHEMBL7992568 | 0.90 | CNR2 (0.36) | CNR2GSK3BKCNH2CYP1A2CYP2D6 | |
| SCHEMBL8224503 | 0.90 | CNR2 (0.36) | CNR2GSK3BKCNH2CYP1A2CYP2D6 | |
| SCHEMBL4510147 | 0.89 | BACE1 (0.32) | BACE1 | |
| SCHEMBL4510146 | 0.89 | BACE1 (0.32) | BACE1 | |
| SCHEMBL8004607 | 0.89 | BACE1 (0.32) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106599-A2 | SUBSTITUTED PIPERIDINES AS THERAPEUTIC COMPOUNDS | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |