Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.70 |
| ▸ | RPTOR | Q8N122 | 12/20 | 0.58 |
| ▸ | MLST8 | Q9BVC4 | 12/20 | 0.58 |
| ▸ | CSF1R | P07333 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL151509 | 1.00 | MTOR (0.70) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL29521594 | 1.00 | MTOR (0.70) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL151508 | 1.00 | MTOR (0.70) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL155581 | 1.00 | MTOR (0.70) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL29522263 | 1.00 | MTOR (0.70) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL157283 | 0.90 | MTOR (0.57) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL155824 | 0.90 | MTOR (0.57) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL17471049 | 0.90 | MTOR (0.57) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL155823 | 0.90 | MTOR (0.57) | MTORPIK3CARPTORMLST8CSF1R | |
| SCHEMBL29522275 | 0.90 | MTOR (0.57) | MTORPIK3CARPTORMLST8CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071658-A1 | PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITOR FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY | PERRIN-NINKOVIC SOPHIE (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071658-A1 | PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITOR FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY | PERRIN-NINKOVIC SOPHIE (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071658-A1 | PYRAZINO[2,3-b]PYRAZINE mTOR KINASE INHIBITOR FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY | MTOR, RICTOR, RPTOR | MTOR 1/4885PIK3CA 6/4885RPTOR 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.