Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8015116 | 0.94 | PDE4B (0.54) | PDE4BMAPK1RPS6KA1NR3C1PDE4D | |
| SCHEMBL13760949 | 0.93 | PDE4B (0.52) | PDE4BMAPK1NR3C1PDE4D | |
| SCHEMBL8016371 | 0.93 | PDE4B (0.51) | PDE4BMAPK1RPS6KA1PDE4D | |
| SCHEMBL3431416 | 0.92 | PDE4B (0.52) | PDE4BMAPK1RPS6KA1NR3C1PDE4D | |
| SCHEMBL13761010 | 0.92 | PDE4B (0.50) | PDE4B | |
| SCHEMBL8014784 | 0.92 | PDE4B (0.50) | PDE4B | |
| SCHEMBL13761185 | 0.92 | PDE4B (0.50) | PDE4B | |
| SCHEMBL8023899 | 0.91 | PDE4B (0.50) | PDE4BMAPK1RPS6KA1 | |
| SCHEMBL8025048 | 0.91 | PDE4B (0.56) | PDE4BMAPK1RPS6KA1NR3C1 | |
| SCHEMBL13761139 | 0.90 | PDE4B (0.50) | PDE4BNR3C1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100166-A1 | DUAL PHARMACOPHORES-PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |