Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.56 |
| ▸ | MTOR | P42345 | 15/20 | 0.56 |
| ▸ | ABL1 | P00519 | 15/20 | 0.56 |
| ▸ | SRC | P12931 | 15/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.56 |
| ▸ | PRKDC | P78527 | 15/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.56 |
| ▸ | EGFR | P00533 | 14/20 | 0.56 |
| ▸ | HCK | P08631 | 14/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1787523 | 0.91 | PIK3CD (0.62) | KDRPIK3CDMTORABL1SRC | |
| SCHEMBL8012344 | 0.90 | PIK3CD (0.56) | KDRPIK3CDMTORABL1SRC | |
| SCHEMBL8006218 | 0.89 | SRC (0.55) | KDRPIK3CDMTORABL1SRC | |
| SCHEMBL1785138 | 0.88 | SRC (0.62) | KDRRETPIK3CDMTORABL1 | |
| SCHEMBL12651288 | 0.88 | ABL1 (0.55) | KDRRETPIK3CDMTORABL1 | |
| SCHEMBL18799891 | 0.84 | PIK3CD (0.57) | KDRRETPIK3CDMTORABL1 | |
| SCHEMBL8008773 | 0.84 | SRC (0.59) | KDRPIK3CDMTORABL1SRC | |
| SCHEMBL8012348 | 0.83 | SRC (0.56) | KDRPIK3CDMTORABL1SRC | |
| SCHEMBL1789264 | 0.82 | PIK3CA (0.51) | KDRRETPIK3CDSRCPIK3CA | |
| SCHEMBL7997108 | 0.82 | SRC (0.57) | KDRRETPIK3CDMTORABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828378-B2 | Kinase inhibitors and methods of use | INTELLIKINE LLC (US) | 2017-11-28 | — | — | US | disclosed |
| US-9637492-B2 | Benzothiazole kinase inhibitors and methods of use | INTELLIKINE LLC (US) | 2017-05-02 | — | — | US | disclosed |
| US-20160024099-A1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC | 2016-01-28 | — | — | US | disclosed |
| EP-2313414-B1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC (US) | 2015-11-04 | — | — | EP | disclosed |
| US-20150225407-A1 | Benzothiazole Kinase Inhibitors and Methods of Use | INTELLIKINE LLC | 2015-08-13 | — | — | US | disclosed |
| US-9096611-B2 | Kinase inhibitors and methods of use | INTELLIKINE LLC (US) | 2015-08-04 | — | — | US | disclosed |
| US-8993580-B2 | Benzothiazole kinase inhibitors and methods of use | INTELLIKINE LLC (US) | 2015-03-31 | — | — | US | disclosed |
| US-20110172228-A1 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC | 2011-07-14 | — | — | US | disclosed |
| US-20110124641-A1 | BENZOTHIAZOLE KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE LLC | 2011-05-26 | — | — | US | disclosed |
| WO-2010006086-A2 | KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE, INC. (US) | 2010-01-14 | — | — | WO | disclosed |
| WO-2009114874-A2 | BENZOTHIAZOLE KINASE INHIBITORS AND METHODS OF USE | INTELLIKINE, INC. (US) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172228-A1 | KINASE INHIBITORS AND METHODS OF USE | PIK3CA, MTOR, PDPK1 | KDR 698/4885RET 443/4885PIK3CD 6/4885 |
| US-20110124641-A1 | BENZOTHIAZOLE KINASE INHIBITORS AND METHODS OF USE | MTOR, PDPK1, PIKFYVE | KDR 1128/4885RET 356/4885PIK3CD 22/4885 |
| US-20150225407-A1 | Benzothiazole Kinase Inhibitors and Methods of Use | MTOR, PDPK1, PIKFYVE | KDR 1128/4885RET 356/4885PIK3CD 22/4885 |
| US-20160024099-A1 | KINASE INHIBITORS AND METHODS OF USE | PIK3CA, MTOR, PDPK1 | KDR 698/4885RET 443/4885PIK3CD 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.