Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.70 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.70 |
| ▸ | ME2 | P23368 | 1/20 | 0.67 |
| ▸ | ME1 | P48163 | 1/20 | 0.67 |
| ▸ | ME3 | Q16798 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12576407 | 0.89 | GRIN1 (0.72) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL12575492 | 0.86 | GRIN1 (0.77) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL8009251 | 0.84 | GRIN1 (0.71) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL2017062 | 0.82 | GRIN1 (1.00) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL7997522 | 0.82 | GRIN1 (0.60) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL13656118 | 0.81 | GRIN1 (0.69) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL8007637 | 0.80 | GRIN1 (0.58) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL8012157 | 0.80 | GRIN1 (0.68) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL2022360 | 0.79 | GRIN1 (0.56) | GRIN1GRIN2BMAPTRAB9AENPP2 | |
| SCHEMBL2022580 | 0.79 | GRIN1 (0.59) | GRIN1GRIN2BMAPTRAB9AENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170334-B1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | UNIV EMORY (US) | 2021-03-17 | — | — | EP | disclosed |
| US-9079852-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2015-07-14 | — | — | US | disclosed |
| US-20140031363-A1 | NMDA Receptor Antagonists for Neuroprotection | LIOTTA DENNIS C (US) | 2014-01-30 | — | — | US | disclosed |
| US-8420680-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| WO-2009137843-A2 | NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS | EMORY UNIVERSITY (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009006437-A1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | EMORY UNIVERSITY (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031363-A1 | NMDA Receptor Antagonists for Neuroprotection | GRIN1, GRIN2C, GRIK1 | GRIN1 1/4885GRIN2B 7/4885ME2 1099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.