Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.50 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999906 | 0.90 | GRN (0.55) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL8013247 | 0.88 | BRD4 (0.51) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL8009899 | 0.88 | KDM4E (0.51) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL5038706 | 0.88 | KDM4E (0.51) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL7998009 | 0.87 | SMN1; SMN2 (0.47) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL5119896 | 0.86 | SMN1; SMN2 (0.54) | CYP1A2POLBSMN1; SMN2MAPTTDP1 | |
| SCHEMBL8007462 | 0.86 | CYP2D6 (0.50) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL7997998 | 0.86 | GRN (0.43) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL7999302 | 0.85 | KDM4E (0.48) | KDM4ECYP1A2GUCY1B2CHRM2HTR1A | |
| SCHEMBL5106101 | 0.83 | SMN1; SMN2 (0.50) | CYP1A2SLC6A4POLBSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |