Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Volinanserin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.80 |
| ▸ | HTR2B | P41595 | 6/20 | 0.80 |
| ▸ | DRD1 | P21728 | 4/20 | 0.80 |
| ▸ | HTR2C | P28335 | 4/20 | 0.80 |
| ▸ | HRH1 | P35367 | 4/20 | 0.80 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.80 |
| ▸ | DRD2 | P14416 | 2/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.80 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.80 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.80 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.80 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.80 |
| ▸ | HTR1D | P28221 | 4/20 | 0.70 |
| ▸ | HTR7 | P34969 | 4/20 | 0.70 |
| ▸ | DRD4 | P21917 | 3/20 | 0.70 |
| ▸ | HRH2 | P25021 | 3/20 | 0.70 |
| ▸ | HTR1B | P28222 | 3/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.70 |
| ▸ | HTR6 | P50406 | 2/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Volinanserin SCHEMBL8010022 | 0.99 | HTR2B (0.78) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL8003439 | 0.99 | HTR2B (0.78) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL7998224 | 0.94 | HTR2B (0.84) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL8008033 | 0.91 | HTR2B (0.89) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL8008450 | 0.90 | HTR2B (0.90) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL13701277 | 0.89 | HTR2B (1.00) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL340674 | 0.89 | HTR2B (1.00) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL29356737 | 0.89 | HTR2B (1.00) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL4227186 | 0.89 | HTR2B (1.00) | HTR2BHTR2ADRD1HTR2CHRH1 | |
| Volinanserin SCHEMBL30543449 | 0.89 | HTR2B (1.00) | HTR2BHTR2ADRD1HTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028083-A | ANTAGONIZE EFFECTS OF SEROTONIN AT THE 5HT.SUB.2A RECEPTOR AND ARE USEFUL IN TREATING VARIOUS CONDITIONS SUCH AS, PSYCHOSES SUCH AS SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 2000-02-22 | — | — | US | claimed |
| US-6063793-A | ANTISEROTONIN AGENTS, PSYCHOLOGICAL DISORDERS AND TREATMENT OF SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 2000-05-16 | — | — | US | disclosed |
| US-6028083-A | ANTAGONIZE EFFECTS OF SEROTONIN AT THE 5HT.SUB.2A RECEPTOR AND ARE USEFUL IN TREATING VARIOUS CONDITIONS SUCH AS, PSYCHOSES SUCH AS SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 2000-02-22 | — | — | US | disclosed |