Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11007898 | 1.00 | EPHX2 (0.44) | EPHX2PTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL11008163 | 1.00 | EPHX2 (0.44) | EPHX2PTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL17784473 | 0.86 | EPHX2 (0.54) | EPHX2FAAHPPARAAPP | |
| SCHEMBL9777768 | 0.86 | EPHX2 (0.54) | EPHX2FAAHPPARAAPP | |
| SCHEMBL9777764 | 0.86 | EPHX2 (0.54) | EPHX2FAAHPPARAAPP | |
| SCHEMBL10978361 | 0.85 | EPHX2 (0.41) | EPHX2PTGS1PDE4ALMNASLC6A6 | |
| SCHEMBL11504503 | 0.82 | EPHX2 (0.65) | EPHX2PTGS1LMNACYP2C19BLM | |
| SCHEMBL11503871 | 0.82 | EPHX2 (0.65) | EPHX2PTGS1LMNACYP2C19BLM | |
| SCHEMBL11504803 | 0.82 | EPHX2 (0.65) | EPHX2PTGS1LMNACYP2C19BLM | |
| SCHEMBL11505198 | 0.82 | EPHX2 (0.65) | EPHX2PTGS1LMNACYP2C19BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1160333-C | Ester of (+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and their use as prodrugs of the 5HT2A receptor antagonist MDL 110,907 | ���µ�˹ҩ�﹫˾ | 2004-08-04 | — | — | CN | disclosed |
| CN-1314887-A | Ester of (+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol and their use as prodrugs of the 5HT2A receptor antagonist MDL 110,907 | AVENTIS PHARMA INC (US) | 2001-09-26 | — | — | CN | disclosed |
| US-6063793-A | ANTISEROTONIN AGENTS, PSYCHOLOGICAL DISORDERS AND TREATMENT OF SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 2000-05-16 | — | — | US | disclosed |
| US-6028083-A | ANTAGONIZE EFFECTS OF SEROTONIN AT THE 5HT.SUB.2A RECEPTOR AND ARE USEFUL IN TREATING VARIOUS CONDITIONS SUCH AS, PSYCHOSES SUCH AS SCHIZOPHRENIA | HOECHST MARION ROUSSEL, INC. (US) | 2000-02-22 | — | — | US | disclosed |
| US-4526900-A | 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease | E. R. SQUIBB & SONS, INC. (US) | 1985-07-02 | — | — | US | disclosed |