Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.65 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13597812 | 0.90 | PIK3CA (0.64) | PIK3CAGRIA2GRIA4PIK3R1CHRNA7 | |
| SCHEMBL8005316 | 0.89 | PIK3CA (0.62) | PIK3CAGRIA2GRIA4PIK3R1MTOR | |
| SCHEMBL3427914 | 0.89 | PIK3CA (0.78) | PIK3CAGRIA2GRIA4PIK3R1MTOR | |
| SCHEMBL8011651 | 0.89 | PIK3CA (0.81) | PIK3CAGRIA2GRIA4PIK3R1ADORA2A | |
| SCHEMBL7998206 | 0.87 | PIK3CA (0.60) | PIK3CAGRIA2GRIA4PIK3R1MTOR | |
| SCHEMBL8006661 | 0.85 | PIK3CA (0.55) | PIK3CAGRIA2GRIA4PIK3R1HSD17B10 | |
| SCHEMBL8008552 | 0.85 | PIK3CA (0.50) | PIK3CAGRIA2GRIA4PIK3R1HSD17B10 | |
| SCHEMBL13597787 | 0.85 | PIK3CA (0.50) | PIK3CAGRIA2GRIA4PIK3R1HSD17B10 | |
| SCHEMBL8006452 | 0.84 | PIK3CA (0.49) | PIK3CAGRIA2GRIA4PIK3R1HSD17B10 | |
| SCHEMBL8006287 | 0.83 | PIK3CA (0.56) | PIK3CAGRIA2GRIA4PIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250160-B1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARM INC (US) | 2015-11-11 | — | — | EP | disclosed |
| US-9029411-B2 | Thiophenes and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20090325925-A1 | Thiophenes and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-12-31 | — | — | US | disclosed |
| WO-2009094224-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325925-A1 | Thiophenes and uses thereof | PIK3CA, JAK2, MTOR | PIK3CA 1/4885GRIA2 2570/4885GRIA4 2350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.