Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.58 |
| ▸ | MTOR | P42345 | 3/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8005706 | 0.92 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8006661 | 0.88 | PIK3CA (0.55) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL3427914 | 0.86 | PIK3CA (0.78) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL3399984 | 0.85 | PIK3CA (0.59) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8006287 | 0.84 | PIK3CA (0.56) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL13597820 | 0.83 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8006078 | 0.83 | PIK3CA (0.56) | PIK3CAMTORPIK3R1CNR2KDM4E | |
| SCHEMBL1550849 | 0.82 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL8008105 | 0.82 | PIK3CA (0.53) | PIK3CAMTORPIK3R1CNR2MAPK1 | |
| SCHEMBL1551282 | 0.81 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250160-B1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARM INC (US) | 2015-11-11 | — | — | EP | disclosed |
| US-9029411-B2 | Thiophenes and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2009094224-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |