Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 10/20 | 0.45 |
| ▸ | CTSK | P43235 | 9/20 | 0.45 |
| ▸ | CTSB | P07858 | 4/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15711996 | 0.91 | KLK5 (0.49) | KLK5LCKCTSSCTSKCTSB | |
| SCHEMBL3013717 | 0.86 | LCK (0.64) | KLK5LCKCTSSCTSKCTSB | |
| SCHEMBL3013721 | 0.86 | LCK (0.64) | KLK5LCKCTSSCTSKCTSB | |
| SCHEMBL10099992 | 0.84 | KLK5 (0.53) | KLK5LCKCTSSCTSKCTSB | |
| SCHEMBL3646270 | 0.83 | KLK5 (0.56) | KLK5CTSSCTSKCTSBACE | |
| SCHEMBL3646266 | 0.83 | KLK5 (0.56) | KLK5CTSSCTSKCTSBACE | |
| SCHEMBL30765061 | 0.83 | KLK5 (0.52) | KLK5LCKCTSSCTSKCTSB | |
| SCHEMBL27125012 | 0.83 | KLK5 (0.52) | KLK5LCKCTSSCTSKCTSB | |
| SCHEMBL24476991 | 0.83 | KLK5 (0.52) | KLK5LCKCTSSCTSKCTSB | |
| SCHEMBL5786508 | 0.83 | KLK5 (0.52) | KLK5LCKCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722923-B2 | Conjugates for treating neurodegenerative diseases and disorders | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2014-05-13 | — | — | US | disclosed |
| WO-2009101616-A9 | NOVEL CONJUGATES FOR TREATING NEURODEGENERATIVE DISEASES AND DISORDERS | RAMOT AT TEL AVIV UNIVERSITY LTD. (IL) | 2010-06-24 | — | — | WO | disclosed |