Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13760886 | 0.96 | PDE4B (0.49) | PDE4BMAPK1RPS6KA1 | |
| SCHEMBL13761163 | 0.95 | PDE4B (0.48) | PDE4BMAPK1RPS6KA1PDE7A | |
| SCHEMBL13761187 | 0.94 | PDE4B (0.48) | PDE4BMAPK1RPS6KA1 | |
| SCHEMBL13760224 | 0.93 | PDE4B (0.47) | PDE4BMAPK1RPS6KA1 | |
| SCHEMBL8014784 | 0.92 | PDE4B (0.50) | PDE4BPDE7A | |
| SCHEMBL8018157 | 0.92 | PDE4B (0.50) | PDE4BMAPK1RPS6KA1PDE7A | |
| SCHEMBL8016371 | 0.92 | PDE4B (0.51) | PDE4BMAPK1RPS6KA1 | |
| SCHEMBL13760978 | 0.92 | PDE4B (0.51) | PDE4BMAPK1RPS6KA1 | |
| SCHEMBL7999785 | 0.91 | PDE4B (0.49) | PDE4BMAPK1RPS6KA1PDE7A | |
| SCHEMBL13760925 | 0.91 | PDE4B (0.49) | PDE4BMAPK1RPS6KA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009100170-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |