Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 2/20 | 0.51 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.51 |
| ▸ | MCTS1 | Q9ULC4 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013898 | 0.87 | HRH1 (0.47) | SLC16A3SLC16A1MCTS1HRH1HRH3 | |
| SCHEMBL8010569 | 0.86 | HRH1 (0.52) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL8005057 | 0.85 | HRH3 (0.50) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL7998873 | 0.84 | HRH3 (0.49) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL8013990 | 0.83 | HRH3 (0.48) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL8013585 | 0.82 | HRH3 (0.47) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL8008523 | 0.81 | KDM4E (0.46) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL8020139 | 0.81 | HRH1 (0.43) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL7997757 | 0.80 | KDM4E (0.54) | HRH1HRH3DRD1KDM4EGUCY1B2 | |
| SCHEMBL8008717 | 0.80 | KCNH2 (0.45) | HRH1HRH3DRD1KDM4EGUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |