Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ACP3 | P15309 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29747857 | 0.91 | GRM1 (0.58) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| SCHEMBL29748155 | 0.91 | GRM1 (0.58) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| SCHEMBL8749855 | 0.91 | GRM1 (0.58) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| SCHEMBL3611200 | 0.91 | GRM1 (0.58) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| SCHEMBL3611197 | 0.91 | GRM1 (0.58) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL3820573 | 0.89 | GRM1 (0.56) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| Hydrochloric Acid SCHEMBL30405940 | 0.89 | GRM1 (0.56) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| SCHEMBL24044801 | 0.77 | MEN1 (0.48) | GRM1MEN1CYP1A2KMT2ATDP1 | |
| SCHEMBL5720952 | 0.77 | CTSA (0.47) | ACP3CTSA | |
| SCHEMBL2320843 | 0.77 | CTSA (0.47) | ACP3CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6054580-A | STERICALLY HINDERED CROWN COMPOUND LIGAND FOR COMPLEXING WITH TRANSITION METAL AS OXIDATION CATALYST RESISTANT TO OXIDIZER DURING USE | CARNEGIE MELLON UNIVERSITY (US) | 2000-04-25 | — | — | US | disclosed |