SCHEMBL800981

SCHEMBL800981

CC(=O)O[C@@H]1C[C@H]2C(C)(C)[C@@H](O)CC[C@]2(C)C2CC[C@]3(C)C(=CC(=O)O[C@H]3c3ccoc3)[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 11/20 1.00
▸ SLCO1B3 Q9NPD5 9/20 1.00
▸ SLCO1B1 Q9Y6L6 9/20 1.00
▸ USP2 O75604 8/20 1.00
▸ SMN1; SMN2 Q16637 5/20 0.88
▸ ALDH1A1 P00352 3/20 0.88
▸ MAPT P10636 3/20 0.88
▸ TP53 P04637 3/20 0.88
▸ TDP1 Q9NUW8 2/20 0.88
▸ HPGD P15428 1/20 0.79
▸ MAPK1 P28482 1/20 0.79
▸ LMNA P02545 1/20 0.63
▸ APEX1 P27695 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10019460 1.00 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
SCHEMBL14196982 1.00 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL13424844 0.93 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL9975312 0.93 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL14196987 0.93 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL13424841 0.93 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL10019459 0.93 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL13424818 0.93 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
3Beta,7Beta-Diacetoxydeoxodeacetoxydeoxydihydrogedunin SCHEMBL10019457 0.93 CYP3A4 (1.00) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2
SCHEMBL10019453 0.88 CYP3A4 (0.81) CYP3A4SLCO1B3SLCO1B1USP2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120071539-A1 COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST EMORY UNIVERSITY (US) 2012-03-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071539-A1 COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST SNRPE, NSUN2, SNRPA CYP3A4 4884/4885SLCO1B3 4482/4885SLCO1B1 4535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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