Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010009 | 1.00 | EGFR (0.42) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8013331 | 0.91 | EGFR (0.42) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8013336 | 0.91 | EGFR (0.42) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8517816 | 0.90 | EGFR (0.42) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8517814 | 0.90 | EGFR (0.42) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8001474 | 0.88 | EGFR (0.40) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8012336 | 0.88 | EGFR (0.40) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8010210 | 0.88 | MEN1 (0.40) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8010211 | 0.88 | MEN1 (0.40) | EGFRMEN1KMT2ACA12CA1 | |
| SCHEMBL8012338 | 0.88 | EGFR (0.40) | EGFRMEN1KMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |
| WO-1999051590-A1 | SUBSTITUTED INDOLINONES AS KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-14 | — | — | WO | disclosed |