Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 5/20 | 0.54 |
| ▸ | TLR2 | O60603 | 5/20 | 0.54 |
| ▸ | MAOA | P21397 | 5/20 | 0.54 |
| ▸ | MAOB | P27338 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010330 | 1.00 | TLR4 (0.54) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL15952706 | 0.94 | MAPT (0.53) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL187779 | 0.94 | MAPT (0.53) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL187778 | 0.94 | MAPT (0.53) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL15952707 | 0.94 | MAPT (0.53) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL10542664 | 0.91 | TLR4 (0.47) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL10542672 | 0.91 | TLR4 (0.47) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL15952366 | 0.90 | MAPT (0.46) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL15952365 | 0.90 | MAPT (0.46) | TLR4TLR2MAOAMAOBMAPT | |
| SCHEMBL15952467 | 0.89 | MAPT (0.45) | TLR4TLR2MAOAMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6160127-A | Process for the preparation of substituted indoles | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0972763-A1 | Process for the preparation of substituted indoles | Bristol-Myers Squibb Company (US) | 2000-01-19 | — | — | EP | disclosed |
| US-5536865-A | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds | L'OREAL (FR) | 1996-07-16 | — | — | US | disclosed |
| US-5508464-A | NITRATING OF A 4,5-DIBENZYLOXYPHENYLACETONITRILE, FOLLOWED BY DEBENZYLATION, HYDROGENATION AND CYCLIZATION | L'OREAL (FR) | 1996-04-16 | — | — | US | disclosed |
| US-5498746-A | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds | L'OREAL (FR) | 1996-03-12 | — | — | US | disclosed |
| US-5410067-A | Catalytic hydrogenation; cyclization | L'OREAL (FR) | 1995-04-25 | — | — | US | disclosed |
| US-4595765-A | Process for preparing 5,6-dihydroxyindole | CLAIROL INCORPORATED (US) | 1986-06-17 | — | — | US | disclosed |
| US-4595765-A | Process for preparing 5,6-dihydroxyindole | CLAIROL INCORPORATED (US) | 1986-06-17 | — | — | US | disclosed |