Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 6/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 6/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 6/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010760 | 0.85 | MAPK1 (0.47) | SMN1; SMN2KDM4ETP53GAAMAPK1 | |
| SCHEMBL8010754 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2KDM4ETP53GAAMAPK1 | |
| SCHEMBL8009905 | 0.81 | MAPT (0.54) | SMN1; SMN2KDM4EGAAMAPK1NPSR1 | |
| SCHEMBL8013247 | 0.79 | BRD4 (0.51) | SMN1; SMN2KDM4EGAAMAPK1NPSR1 | |
| SCHEMBL8010101 | 0.78 | GCK (0.43) | NPC1RAB9ASMN1; SMN2KDM4EGAA | |
| SCHEMBL7998139 | 0.77 | TRPV1 (0.47) | NPC1RAB9ASMN1; SMN2KDM4ENFKB1 | |
| SCHEMBL8007462 | 0.77 | CYP2D6 (0.50) | NPC1KDM4EGAAMAPK1NPSR1 | |
| SCHEMBL8007918 | 0.77 | NPC1 (0.47) | CASP3SENP7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8008245 | 0.77 | NPSR1 (0.48) | KDM4EGAAMAPK1NPSR1ALDH1A1 | |
| SCHEMBL8010517 | 0.77 | NPSR1 (0.52) | KDM4EGAAMAPK1NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027394-A1 | ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | UNIVERSITY COLLEGE LONDON (GB) | 2000-05-18 | — | — | WO | disclosed |