Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.75 |
| ▸ | GRIA4 | P48058 | 9/20 | 0.66 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010064 | 0.88 | PIK3CA (0.80) | PIK3CAGRIA4GRIA2PIK3R1MTOR | |
| SCHEMBL8012135 | 0.88 | PIK3CA (0.64) | PIK3CAGRIA4GRIA2PIK3R1NPC1 | |
| SCHEMBL8008374 | 0.87 | PIK3CA (0.81) | PIK3CAGRIA4GRIA2PIK3R1MTOR | |
| SCHEMBL8011651 | 0.87 | PIK3CA (0.81) | PIK3CAGRIA4GRIA2PIK3R1NPC1 | |
| SCHEMBL3403319 | 0.86 | PIK3CA (0.80) | PIK3CAGRIA4GRIA2PIK3R1MTOR | |
| SCHEMBL8006300 | 0.86 | PIK3CA (1.00) | PIK3CAGRIA4GRIA2PIK3R1MTOR | |
| SCHEMBL3402690 | 0.84 | PIK3CA (0.77) | PIK3CAGRIA4GRIA2PIK3R1MTOR | |
| SCHEMBL13597791 | 0.82 | PIK3CA (0.56) | PIK3CAGRIA4GRIA2PIK3R1NPC1 | |
| SCHEMBL8008359 | 0.81 | PIK3CA (0.72) | PIK3CAGRIA4GRIA2PIK3R1MTOR | |
| SCHEMBL3403807 | 0.81 | PIK3CA (0.78) | PIK3CAGRIA4GRIA2PIK3R1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250160-B1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARM INC (US) | 2015-11-11 | — | — | EP | disclosed |
| US-9029411-B2 | Thiophenes and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2009094224-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |