Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.31 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triethylene Glycol SCHEMBL1073837 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Propylene Glycol SCHEMBL8851429 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Tetraethylene Glycol SCHEMBL8850597 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Hexaethylene Glycol SCHEMBL16673171 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Triethylene Glycol SCHEMBL6869496 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Triethylene Glycol SCHEMBL22077278 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Propylene Glycol SCHEMBL8851056 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Propylene Glycol SCHEMBL3359839 | 1.00 | MEN1 (0.61) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Triethylene Glycol SCHEMBL6314263 | 0.97 | MEN1 (0.58) | MEN1KMT2ATSHRTDP1MAPK1 | |
| Di(Hydroxyethyl)Ether SCHEMBL3063890 | 0.97 | TSHR (0.59) | MEN1KMT2ATSHRTDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046258-A | COMPOSITION COMPRISING FUMARIC ACID-NEOPENTYL GLYCOL-PROPYLENE GLYCOL POLYESTER, CUMENE HYDROPEROXIDE HARDENER, DEHYDRATABLE INORGANIC FILLER, REINFORCING MATERIAL | MITSUBISHI DENKI KABUSHIKI KAISHA (JP) | 2000-04-04 | — | — | US | disclosed |