Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 7/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013275 | 1.00 | AKT2 (0.42) | AKT2PDPK1EGFRCA12CA1 | |
| SCHEMBL8013337 | 0.93 | AKT2 (0.42) | AKT2PDPK1EGFRCA12CA1 | |
| SCHEMBL8013333 | 0.93 | AKT2 (0.42) | AKT2PDPK1EGFRCA12CA1 | |
| SCHEMBL8001273 | 0.92 | AKT2 (0.40) | AKT2PDPK1EGFRCA12CA1 | |
| SCHEMBL8001267 | 0.92 | AKT2 (0.40) | AKT2PDPK1EGFRCA12CA1 | |
| SCHEMBL8001456 | 0.91 | AKT2 (0.41) | AKT2PDPK1EGFRCA12CA1 | |
| SCHEMBL8001454 | 0.91 | AKT2 (0.41) | AKT2PDPK1EGFRCA12CA1 | |
| SCHEMBL8010210 | 0.89 | MEN1 (0.40) | EGFRCA12CA1CA2CA9 | |
| SCHEMBL8010211 | 0.89 | MEN1 (0.40) | EGFRCA12CA1CA2CA9 | |
| SCHEMBL8012398 | 0.89 | AKT2 (0.41) | AKT2PDPK1EGFRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6043254-A | ANTIPROLIFERATIVE AGENT; ENZYME INHIBITOR | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-28 | — | — | US | disclosed |