Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 2/20 | 0.38 |
| ▸ | ARG2 | P78540 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022491 | 1.00 | SPHK1 (0.42) | SPHK1GNAI3GNAO1GNAI1KCNA3 | |
| SCHEMBL4022189 | 0.98 | KCNA3 (0.41) | SPHK1GNAI3GNAO1GNAI1KCNA3 | |
| SCHEMBL1099388 | 0.91 | KCNA3 (0.42) | SPHK1GNAI3GNAO1GNAI1KCNA3 | |
| SCHEMBL1099705 | 0.82 | KCNA3 (0.44) | SPHK1KCNA3HRH3ARG1ARG2 | |
| SCHEMBL8015299 | 0.81 | SPHK1 (0.44) | SPHK1GNAI3GNAO1GNAI1KCNA3 | |
| SCHEMBL8022494 | 0.81 | SPHK1 (0.44) | SPHK1GNAI3GNAO1GNAI1KCNA3 | |
| SCHEMBL4295354 | 0.79 | PDCD1 (0.48) | KCNA3HRH3HRH2HRH1 | |
| SCHEMBL4295715 | 0.79 | PDCD1 (0.48) | KCNA3HRH3HRH2HRH1 | |
| SCHEMBL1360021 | 0.79 | PDCD1 (0.48) | KCNA3HRH3HRH2HRH1 | |
| SCHEMBL8860724 | 0.79 | SPHK1 (0.42) | SPHK1GNAI3GNAO1GNAI1KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666265-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2000-01-26 | — | — | EP | disclosed |
| US-5527786-A | ANTIDIABETIC AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0666265-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-08-09 | — | — | EP | disclosed |