SCHEMBL8017223

SCHEMBL8017223

COc1ccccc1OC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.75

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 14/20 0.74
SRD5A2 P31213 7/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8006816 0.90 SRD5A1 (0.70) SRD5A1SRD5A2
SCHEMBL8016927 0.89 SRD5A1 (0.64) SRD5A1SRD5A2
SCHEMBL8156051 0.88 SRD5A1 (0.74) SRD5A1SRD5A2
SCHEMBL8156054 0.88 SRD5A1 (0.74) SRD5A1SRD5A2
SCHEMBL8006821 0.87 SRD5A1 (0.76) SRD5A1SRD5A2
SCHEMBL8007033 0.87 SRD5A1 (0.75) SRD5A1SRD5A2
SCHEMBL13403338 0.86 SRD5A1 (0.73) SRD5A1SRD5A2
SCHEMBL14355654 0.86 SRD5A1 (0.73) SRD5A1SRD5A2
SCHEMBL14295225 0.86 SRD5A1 (0.73) SRD5A1SRD5A2
SCHEMBL13970874 0.86 SRD5A1 (0.73) SRD5A1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0664812-B1 17-BETA-ARYL ESTER CARBOXYLATES OF 4-AZA-5-ALPHA-ANDROSTANE-3-ONES MERCK & CO INC (US) 2000-01-05 EP claimed
US-5278159-A Steroid enzyme inhibitor MERCK & CO., INC. (US) 1994-01-11 US disclosed