Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sergliflozin Etabonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 known ✓ | P31639 | 17/20 | 1.00 |
| ▸ | SLC5A1 | P13866 | 13/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sergliflozin Etabonate SCHEMBL15827906 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1CYP3A4CYP2C19NPC1 | |
| Sergliflozin Etabonate SCHEMBL621807 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1CYP3A4CYP2C19NPC1 | |
| Sergliflozin Etabonate SCHEMBL16421550 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1CYP3A4CYP2C19NPC1 | |
| Sergliflozin Etabonate SCHEMBL621808 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1CYP3A4CYP2C19NPC1 | |
| Sergliflozin Etabonate SCHEMBL18058588 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1CYP3A4CYP2C19NPC1 | |
| Sergliflozin Etabonate SCHEMBL23731198 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1CYP3A4CYP2C19NPC1 | |
| SCHEMBL14634632 | 0.96 | SLC5A2 (0.93) | SLC5A2SLC5A1NPC1RAB9A | |
| SCHEMBL14634627 | 0.96 | SLC5A2 (0.93) | SLC5A2SLC5A1NPC1RAB9A | |
| SCHEMBL874080 | 0.96 | SLC5A2 (0.93) | SLC5A2SLC5A1NPC1RAB9A | |
| SCHEMBL4360297 | 0.92 | SLC5A2 (0.86) | SLC5A2SLC5A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252591-B1 | ARYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF | SANOFI AVENTIS (FR) | 2011-06-22 | — | — | EP | disclosed |
| WO-2009097999-A1 | ARYL-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-08-13 | — | — | WO | disclosed |