SCHEMBL8020274

SCHEMBL8020274

COc1cccc(C2CC[C@H]3[C@@H]4CCC5NC(=O)C=C[C@]5(C)[C@@H]4CC[C@]23C)c1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 15/20 0.66
SRD5A2 P31213 10/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8023133 0.89 SRD5A1 (0.67) SRD5A1SRD5A2
SCHEMBL8159352 0.89 SRD5A1 (0.67) SRD5A1SRD5A2
SCHEMBL8163315 0.88 SRD5A1 (0.67) SRD5A1SRD5A2
SCHEMBL8163312 0.88 SRD5A1 (0.67) SRD5A1SRD5A2
SCHEMBL8006679 0.86 SRD5A1 (0.57) SRD5A1SRD5A2
SCHEMBL8155921 0.86 SRD5A1 (0.66) SRD5A1SRD5A2
SCHEMBL8155923 0.86 SRD5A1 (0.66) SRD5A1SRD5A2
SCHEMBL8021087 0.85 SRD5A1 (0.57) SRD5A1SRD5A2
SCHEMBL8016786 0.85 SRD5A1 (0.64) SRD5A1SRD5A2
SCHEMBL8158280 0.83 SRD5A1 (0.57) SRD5A1SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0664812-B1 17-BETA-ARYL ESTER CARBOXYLATES OF 4-AZA-5-ALPHA-ANDROSTANE-3-ONES MERCK & CO INC (US) 2000-01-05 EP claimed