Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020305 | 1.00 | POLB (0.46) | POLBSMN1; SMN2ALOX15TSHRERCC5 | |
| SCHEMBL11541352 | 0.86 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2ALOX15TSHRL3MBTL1 | |
| SCHEMBL11541350 | 0.86 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2ALOX15TSHRL3MBTL1 | |
| SCHEMBL7832135 | 0.85 | HTT (0.42) | POLBSMN1; SMN2L3MBTL1MAPTNPC1 | |
| SCHEMBL7922301 | 0.83 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2TSHRL3MBTL1MAPT | |
| SCHEMBL8022234 | 0.82 | POLB (0.49) | POLBSMN1; SMN2ALOX15TSHRERCC5 | |
| SCHEMBL8022236 | 0.82 | POLB (0.49) | POLBSMN1; SMN2ALOX15TSHRERCC5 | |
| SCHEMBL31264414 | 0.82 | POLB (0.49) | POLBSMN1; SMN2ALOX15TSHRERCC5 | |
| SCHEMBL7822539 | 0.81 | ERCC5 (0.49) | SMN1; SMN2ERCC5FEN1NPC1RAB9A | |
| SCHEMBL9660178 | 0.80 | HSP90AA1 (0.50) | POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675133-B1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5693809-A | PREGNANES FOR TREATING ALOPECIA, ACNE AND SKIN DISORDER | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5614470-A | AGRICULTURAL ANTHELMINTIC, ACARICIDE, INSECTICIDE | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0675133-A1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1995-10-04 | — | — | EP | disclosed |