Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.87 |
| ▸ | GAA | P10253 | 3/20 | 0.84 |
| ▸ | MAPT | P10636 | 3/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.84 |
| ▸ | GFER | P55789 | 1/20 | 0.84 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.70 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.66 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.62 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.60 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.60 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1300190 | 0.93 | HPGD (1.00) | HPGDGAAMAPTMEN1KMT2A | |
| SCHEMBL19703413 | 0.93 | HPGD (1.00) | HPGDGAAMAPTMEN1KMT2A | |
| SCHEMBL4668488 | 0.91 | HPGD (0.96) | HPGDGAAMAPTMEN1KMT2A | |
| SCHEMBL19501631 | 0.90 | HPGD (0.87) | HPGDGAAMAPTMEN1KMT2A | |
| SCHEMBL31401950 | 0.88 | HPGD (0.83) | HPGDGAAMAPTMEN1KMT2A | |
| SCHEMBL2184247 | 0.88 | HPGD (0.89) | HPGDGAAMAPTMEN1KMT2A | |
| SCHEMBL28656982 | 0.88 | PTPN1 (0.89) | HPGDMAPTMEN1KMT2APTPN1 | |
| SCHEMBL125695 | 0.88 | PTPN1 (0.89) | HPGDMAPTMEN1KMT2APTPN1 | |
| SCHEMBL25730750 | 0.87 | HPGD (0.87) | HPGDGAAMAPTMEN1KMT2A | |
| SCHEMBL22678640 | 0.84 | HPGD (0.81) | HPGDGAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030992-A | ANTAGONISTS FOR THE BINDING OF NEUROKININ-2 RECEPTOR; SLEEP DISORDERS; BENZIMIDES, 2- OR 3-ALKOXYBENZIMIDES AND 2,3-DIALKOXYBENZIMIDES | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-6025379-A | A SUBSTITUTED BENZIMIDAZOLE, TACHYKININ RECEPTOR ANTAGONISTS, | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1997031635-A1 | METHODS OF TREATING OR PREVENTING SLEEP APNEA | ELI LILLY AND COMPANY (US) | 1997-09-04 | — | — | WO | disclosed |
| US-5552426-A | NERVOUS SYSTEM DISORDERS USING IMIDAZOLE DERIVITIVES | ELI LILLY AND COMPANY (US) | 1996-09-03 | — | — | US | disclosed |
| EP-0694535-A1 | Non-peptidyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-01-31 | — | — | EP | disclosed |