SCHEMBL8020813 — predicted protein targets

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	AVPR1B	P47901	13/20	0.55

▸	SMN1; SMN2	Q16637	2/20	0.37

▸	ABL1	P00519	1/20	0.35

▸	TRPV3	Q8NET8	1/20	0.35

▸	CNR2	P34972	1/20	0.34

▸	HPGD	P15428	2/20	0.34

▸	LMNA	P02545	1/20	0.34

▸	MAPT	P10636	1/20	0.34

▸	NLRP1	Q9C000	1/20	0.34

▸	CNR1	P21554	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4304919	0.89	AVPR1B (0.56)	AVPR1BTRPV3
SCHEMBL4308294	0.89	AVPR1B (0.54)	AVPR1BSMN1; SMN2
SCHEMBL4307482	0.86	AVPR1B (0.55)	AVPR1BSMN1; SMN2
SCHEMBL4308493	0.85	AVPR1B (0.54)	AVPR1BSMN1; SMN2
SCHEMBL4305688	0.81	AVPR1B (0.81)	AVPR1B
SCHEMBL8018283	0.80	AVPR1B (0.41)	AVPR1BSMN1; SMN2
SCHEMBL4304194	0.80	AVPR1B (0.52)	AVPR1BSMN1; SMN2
SCHEMBL8026823	0.75	AVPR1B (0.47)	AVPR1BTRPV3
SCHEMBL8019748	0.73	AVPR1B (0.52)	AVPR1B
SCHEMBL4305913	0.71	AVPR1B (0.40)	AVPR1BSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009130232-A1	PYRAZOLO [1, 5 -A] PYRAZINE DERIVATIVES AS ANTAGONISTS OF V1B RECEPTORS	GLAXO GROUP LIMITED (GB)	2009-10-29	—	—	WO	disclosed