Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTAFR | P25105 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976682 | 1.00 | NAMPT (0.46) | NAMPTGLAPOLBHPGDHTT | |
| SCHEMBL7976678 | 1.00 | NAMPT (0.46) | NAMPTGLAPOLBHPGDHTT | |
| SCHEMBL7980167 | 0.92 | PTAFR (0.46) | NAMPTPOLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL7980165 | 0.92 | PTAFR (0.46) | NAMPTPOLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL7979927 | 0.89 | NAMPT (0.49) | NAMPTPOLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL7978580 | 0.89 | NAMPT (0.49) | NAMPTPOLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL7976863 | 0.84 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2PTAFR | |
| SCHEMBL7980129 | 0.84 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2PTAFR | |
| SCHEMBL7976881 | 0.84 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2PTAFR | |
| SCHEMBL7966197 | 0.84 | PTAFR (0.42) | POLBHPGDHTTSMN1; SMN2PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |