Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thiothixene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.91 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.91 |
| ▸ | LMNA | P02545 | 6/20 | 0.91 |
| ▸ | DRD3 | P35462 | 6/20 | 0.91 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.91 |
| ▸ | HTR1A | P08908 | 5/20 | 0.91 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.91 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.91 |
| ▸ | HRH1 | P35367 | 5/20 | 0.91 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.91 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.91 |
| ▸ | DRD1 | P21728 | 5/20 | 0.91 |
| ▸ | MEN1 | O00255 | 4/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.91 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.91 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.91 |
| ▸ | HTR2C | P28335 | 3/20 | 0.91 |
| ▸ | USP2 | O75604 | 3/20 | 0.91 |
| ▸ | HTR6 | P50406 | 3/20 | 0.91 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiothixene SCHEMBL782605 | 0.95 | CYP3A4 (1.00) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL3715363 | 0.95 | CYP3A4 (1.00) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL29373233 | 0.95 | CYP3A4 (1.00) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL34305 | 0.95 | CYP3A4 (1.00) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL29391417 | 0.95 | CYP3A4 (1.00) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL718331 | 0.95 | CYP3A4 (1.00) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL561321 | 0.94 | MEN1 (1.00) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL40977 | 0.94 | MEN1 (0.98) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL30903897 | 0.94 | MEN1 (0.98) | CYP3A4LMNADRD3CYP2D6HTR1A | |
| Thiothixene SCHEMBL721093 | 0.93 | CYP3A4 (0.94) | CYP3A4LMNADRD3CYP2D6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6060642-A | TRANSGENIC MICE MODELS FOR GENE FUNCTION, WHEREIN THE TRANSGENIC MICE ARE CHARACTERIZED BY HAVING ALTERED SEROTONIN 5-HT6 RECEPTOR GENE FUNCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-05-09 | — | — | US | disclosed |