Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 4/20 | 0.44 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octanedioate SCHEMBL21048736 | 0.97 | TDP1 (0.70) | TDP1LMNATSHRNFKB1PMP22 | |
| SCHEMBL269896 | 0.89 | TDP1 (0.93) | TDP1LMNATSHRSLC22A6FOLH1 | |
| SCHEMBL30018041 | 0.88 | TDP1 (0.64) | TDP1LMNATSHRNFKB1PMP22 | |
| SCHEMBL22151 | 0.86 | TDP1 (1.00) | TDP1LMNATSHRSLC22A6FOLH1 | |
| SCHEMBL17517216 | 0.86 | TDP1 (1.00) | TDP1LMNATSHRSLC22A6FOLH1 | |
| SCHEMBL16925719 | 0.86 | TDP1 (1.00) | TDP1LMNATSHRSLC22A6FOLH1 | |
| SCHEMBL165643 | 0.86 | TDP1 (1.00) | TDP1LMNATSHRSLC22A6FOLH1 | |
| SCHEMBL1318745 | 0.83 | TDP1 (0.93) | TDP1LMNATSHRSLC22A6FOLH1 | |
| SCHEMBL9678882 | 0.83 | TDP1 (0.93) | TDP1LMNATSHRSLC22A6FOLH1 | |
| SCHEMBL9355977 | 0.83 | TDP1 (0.93) | TDP1LMNATSHRSLC22A6FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000086574-A | PRODUCTION OF CARBOXYLIC ACIDS | NOYORI RYOJI | 2000-03-28 | — | — | JP | disclosed |