Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 4/20 | 0.49 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.49 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.49 |
| ▸ | PAOX | Q6QHF9 | 4/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9978410 | 1.00 | KDM5A (0.49) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL12513177 | 1.00 | KDM5A (0.49) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL8025386 | 0.91 | KDM5A (0.51) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL17297348 | 0.91 | KDM5A (0.51) | KDM5APHF8KDM2AKDM4CKDM7A | |
| SCHEMBL10811442 | 0.91 | — | — | |
| SCHEMBL5274891 | 0.90 | KDM5A (0.53) | KDM5APHF8KDM2AKDM4CPAOX | |
| SCHEMBL8814713 | 0.90 | KDM5A (0.53) | KDM5APHF8KDM2AKDM4CPAOX | |
| SCHEMBL15177356 | 0.90 | KDM5A (0.53) | KDM5APHF8KDM2AKDM4CPAOX | |
| SCHEMBL7909306 | 0.90 | KDM5A (0.53) | KDM5APHF8KDM2AKDM4CPAOX | |
| SCHEMBL9571984 | 0.90 | MAPT (0.44) | KDM5APHF8KDM2AKDM4CKDM7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598484-B1 | PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | LEK PHARMACEUTICALS (SI) | 2016-06-29 | — | — | EP | claimed |
| EP-0668258-B1 | Process for the preparation of 1-cyclopropylalkane-1,3-diones | HUELS CHEMISCHE WERKE AG (DE) | 1998-04-15 | — | — | EP | claimed |
| EP-0297345-B2 | AZOLYLMETHYLCYCLOPROPYL DERIVATIVES | BAYER AG (DE) | 1993-10-13 | — | — | EP | claimed |
| EP-0298332-B1 | HYDROXY-ALKYLAZOLYL DERIVATIVES | BAYER AG (DE) | 1990-11-28 | — | — | EP | claimed |
| EP-0297383-B1 | HYDROXYETHYL-AZOLYL DERIVATIVES | BAYER AG (DE) | 1990-10-10 | — | — | EP | claimed |
| EP-0973708-A1 | IMPROVED PROCESS FOR PREPARING CYCLOPROPYLACETYLENE | BASF AKTIENGESELLSCHAFT (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040333-A1 | IMPROVED PROCESS FOR PREPARING CYCLOPROPYLACETYLENE | BASF AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |